Low melanoma incidence area or population	Moderate to high melanoma incidence area or population
Two (synchronous or metachronous) primary melanomas in an individual OR	Three (synchronous or metachronous) primary melanomas in an individual OR
Families with at least one invasive melanoma and one or more other diagnoses of melanoma and/or pancreatic cancers among first- or second-degree relatives on the same side of the family	Families with at least one invasive melanoma and two or more other diagnoses of melanoma and/or pancreatic cancers among first- or second-degree relatives on the same side of the family