Group	Hereditary melanoma	FAMMM syndrome	CDKN2A mutation	Clinical management
Group 1				CDKN2A-specific recommendations Genetic counselling and encourage screening of family members Education on skin protection three to six-monthly skin checks, including scalp, oral and genital mucosa from puberty onwards Suspicious lesions should be reviewed regularly with the use of total body photography and/or dermoscopy and have a lower threshold for biopsies Advice to stop smoking Education on possibility of increased pancreatic cancer risk ± regular screening FAMMM syndrome-specific recommendations Advice that in FAMMM syndrome lesions may arise from melanocytic naevi and from normal skin Skin checks to pay extra attention to the trunk
	Y	Y	Y
Group 2				Genetic counselling ± the offer of further testing for other high to intermediate penetrance genes Same as Group 1, including the recommendations for CDKN2A-specific recommendations, except without the education regarding pancreatic cancer risk
	Y	Y	N
Group 3				Same as Group 1 but without the FAMMM syndrome-specific recommendations
	Y	N	Y
Group 4				Education on skin protection six to 12-monthly skin checks Suspicious lesions should be reviewed regularly and have a lower threshold for biopsies
	Y	N	N