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AJOPS | CASE REPORT
PUBLISHED: 31-03-2021

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Parotid mucoepidermoid carcinoma with extensive intravenous metastasis: a case report

Alice Flavell-Birch MBChB,1 Helen D Brasch MBChB FRCPA,2 Swee T Tan MBBS FRACS PhD1,2

1 

Wellington Regional Plastic, Maxillofacial and Burns Unit
Hutt Hospital
Wellington
NEW ZEALAND

 

Gillies McIndoe Research Institute
Wellington
NEW ZEALAND

OPEN ACCESS
Correspondence
Name:
Swee T Tan
Address:
Gillies McIndoe Research Institute
PO Box 7184
Newtown 6242
Wellington
NEW ZEALAND
Email:
[email protected]
Phone:
+61 (0)4 282 0366
Citation:
Flavell-Birch A, Brasch HD, Tan ST. Parotid mucoepidermoid carcinoma with extensive intravenous metastasis: a case report. Australas J Plast Surg. 2021;4(1):71–74. DOI https://doi.org/10.34239/ajops.v4n1.244
Manuscript received: 6 July 2020
Manuscript revised: 7 November 2020
Manuscript accepted: 8 December 2020
Copyright © 2021.
Authors retain their copyright in the article. This is an open access article distributed under the Creative Commons Attribution Licence 4.0 which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
Section:
Head and neck


Background

Salivary tumours are uncommon, comprising only 2–5 per cent of head and neck neoplasms,1 with mucoepidermoid carcinoma (MEC) being the most common salivary cancer in both adults and children.1–4 Clinically, head and neck MEC can present variably from being asymptomatic to locally or metastatically aggressive.5,6 Treatment is primary surgical resection with neck dissection. The use of adjuvant radiotherapy is indicated for patients at high risk of recurrence, such as those with a high tumour stage, positive resection margins and high histological grading.6–8

Keywords: mucoepidermoid carcinoma, head and neck neoplasm, parotid gland


Case report

A 57-year-old otherwise well male presented with a six-month history of a progressive, non-tender right parotid swelling associated with occasional right-sided tinnitus and headaches. There was normal cranial nerve function and no cervical lymphadenopathy. Fine needle aspiration cytology demonstrated MEC. Magnetic resonance imaging and CT scans showed a 1.5 cm tumour within the superficial lobe of the right parotid gland and a bulky tumour within the markedly distended retromandibular vein (RMV) and its tributaries within the masseter muscle and those that extend medially around the vertical ramus of the mandible into the infratemporal fossa towards the pterygoid plexus. The tumour within the distended RMV and common facial vein (CFV) extended into the internal jugular vein (IJV) from the level of the angle of the mandible to the level of the cricoid cartilage (Figure 1a and b). The RMV was not connected with the external jugular vein, which was free of tumour. Staging CT showed no nodal metastasis or disease elsewhere.

Fig 1. A coronal MRI T2 sequence through the parotid gland (A) and more anteriorly (B), demonstrating the tumour within the distended right retromandibular vein (RMV) and its tributaries in the infratemporal fossa (ITFV), contiguous with the internal jugular vein (IJV) down to the level of cricoid cartilage, with its lumen clear of tumour superiorly.

The patient was managed by a head and neck multidisciplinary team and underwent a right total parotidectomy with facial nerve preservation, resection of the masseteric muscle and the infratemporal fossa and ipsilateral modified radical neck dissection, achieving clear macroscopic margins. The IJV was ligated superiorly below the skull base and inferiorly below the level of the hyoid bone and was removed en bloc with the parotidectomy and neck dissection specimen (Figure 2a–d). The tumour appeared to be entirely within the aforementioned greatly distended venous network as one contiguous metastatic deposit without obvious involvement of the parotid gland.

Fig 2. Intraoperative images. (A) Surgical markings with shaded area indicating the palpable tumour within the distended retromandibular vein (RMV). (B) The facial nerve (arrow) overlying the greatly distended RMV with the parotid gland (PG) retracted superiorly. The sternocleidomastoid muscle (SM) was resected preserving the accessory nerve (AN) and the internal jugular vein (IJV) was ligated. (C) Lateral view of the surgical specimen demonstrating the distended RMV, its tributaries within the masseter muscle (MV), and the infratemporal fossa (ITFV), joined by the common facial vein (CFV) as they drained into the IJV. (D) Intravascular tumour within the distended RMV (arrow). SG=submandibular gland.

Histology demonstrated an intermediate-grade MEC within the superficial lobe of the parotid gland (Figure 3a and b) with sheets of necrosis present within the tumour. The tumour cells were predominantly mildly to moderately pleomorphic, with occasional markedly pleomorphic cells. Periodic acid-Schiff-diastase staining showed intracytoplasmic mucin. There was extensive intravenous tumour with no direct extension from the primary tumour into the adjacent blood or lymphatic vessels and there was no nodal metastasis. Tumour was present at a resection margin microscopically within a single vein deep to the masseter muscle.

Fig 3. Haematoxylin and eosin staining of (A) the primary tumour within the parotid gland showing mixed solid and cystic architecture comprising a mixture of predominantly intermediate and squamous cells, surrounding pools of mucin (arrowheads) in a cribriform architecture with microcysts, and (B) metastatic tumour (short arrows) within the lumen of a vein (long arrows). Nuclei were counterstained with haematoxylin (A&B). Original magnifications: A, 100×; B, 200×.

The patient was followed up by the multidisciplinary team. Apart from temporary partial neuropraxia of the right facial nerve, the postoperative course was uneventful and the patient was discharged on day four and subsequently completed adjuvant radiotherapy as part of the original treatment plan. At follow-up 14 months postoperatively, the patient had normal facial nerve function and no clinical sign of local or regional recurrence (Figure 4)

Fig 4. Clinical photographs at 14 months postoperatively demonstrating full function of the right facial nerve.

Discussion

Risk factors for developing MEC include previous radiation exposure, smoking and viral infections such as human papillomavirus.2,9 Histological grading provides the best prognostic factor for survival, with high-grade tumours being the most aggressive.9,10

Mucoepidermoid carcinoma tends to disseminate initially via lymphatic channels which are typically thin-walled and leaky compared with the multi-layered blood vessel walls.1,5 Similarly, cancer cells that spread haematogenously enter the small capillaries then larger vessels via the venous network. The propensity for lymphatic or haematogenous invasion with metastatic MEC has not been fully identified but is thought to be related to tumour cell markers and enzymes.4,5

Tumours that commonly metastasise intravascularly include renal cell carcinoma and hepatocellular carcinoma.5 Histological evaluation may identify penetration of small vessels adjacent to the primary tumour, which suggests the development of metastatic disease.5 In the case presented, the behaviour of the tumour was unusual—a small primary tumour with extensive intravenous involvement without direct invasion of the veins, perivascular or lymphatics. Although it is possible that lymphatics could have carried the tumour cells into the neck veins via small connecting channels, neither lymphatic nor capillary involvement was observed.

Conclusion

This case of MEC of the parotid is unusual in that a small primary tumour was associated with extensive ipsilateral intravenous metastasis without direct invasion of the involved veins.

Acknowledgements

The authors would like to thank Dr Claire French, pathology registrar at Wellington SCL, Hutt Hospital, New Zealand, Dr Hannah Kim, radiologist and Dr Eric Ji, radiation oncologist, Wellington Regional Hospital, New Zealand, for their assistance.

Disclosure

The authors have no financial or commercial conflicts of interest to disclose.

References

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